Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Shserpin-p46
- Development stage
- Preclinical
- Lead developer
- Midwestern University
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
01
Overview
Shserpin-p46 is a recombinant protein subunit vaccine candidate under preclinical development for the prevention of urogenital schistosomiasis caused by *Schistosoma haematobium*. The vaccine antigen is a secretory serine protease inhibitor (serpin) from *S. haematobium* that is expressed during the intra-mammalian life cycle stages and localized to the parasite's tegument. Shserpin-p46 acts by inhibiting host neutrophil elastase, a key serine protease involved in host immune responses, thereby preventing parasite evasion. Formulated with proprietary TLR4-agonist-based adjuvants, EmT4 and LiT4Q, Shserpin-p46 is designed to induce protective immune responses and disease resistance.
- Other names
- Schistosoma haematobium serine protease inhibitor p46rShserpin-p46rShserpin-p-46rShserpin-p 46recombinant Shserpin-p46
02
Targets
ELANE (Human Neutrophil Elastase)TLR4 (Toll-like receptor 4)
Beyond the preview
Go deeper on Shserpin-p46.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Shserpin-p46.