Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
shSIRT5
- Development stage
- Preclinical
- Lead developer
- Huazhong University of Science and Technology
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
shSIRT5 is a short hairpin RNA (shRNA) construct designed to silence the expression of Sirtuin 5 (SIRT5), an NAD+-dependent deacylase. In the context of acute myeloid leukemia (AML) research, SIRT5 knockdown via shSIRT5 has been shown to increase the succinylation of mitochondrial trifunctional enzyme subunit alpha (HADHA), thereby inhibiting fatty acid oxidation (FAO) and mitochondrial oxidative phosphorylation. This metabolic disruption increases mitochondrial reactive oxygen species (ROS) and sensitizes AML cells to BCL2 inhibitors like venetoclax. The construct is typically delivered via lentiviral transduction for in vitro and in vivo preclinical studies.
- Other names
- SIRT5 shRNASIRT-5 shRNASIRT 5 shRNAshort hairpin RNA targeting SIRT5
02
Targets
SIRT5 (NAD-dependent protein deacylase sirtuin-5, mitochondrial)
Beyond the preview
Go deeper on shSIRT5.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on shSIRT5.