Drug intelligence / Profile preview

Shu Nao Xin Dripping Pill

Development stage
Unknown
Lead developer
Tianjin Zhongxin Pharmaceutical Group No. 6 Chinese Medicine Plant
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Shu Nao Xin Dripping Pill (also known as Shunaoxin Dripping Pill or Shu Nao Xin Di Wan) is a traditional Chinese medicine (TCM) developed and manufactured by Tianjin Pharmaceutical Da Ren Tang Group (formerly Tianjin Zhongxin Pharmaceutical Group). It is formulated as a solid dispersion dripping pill containing extracts from two primary herbal ingredients: *Ligusticum chuanxiong* (Chuanxiong) and *Angelica sinensis* (Danggui). The preparation is clinically approved in China (since 2005) for the treatment of cerebrovascular and cardiovascular diseases, particularly migraine, dizziness, blurred vision, amnesia, and insomnia caused by blood deficiency and blood stasis. Pharmacologically, Shu Nao Xin Dripping Pill regulates qi, promotes blood circulation, removes blood stasis, and exerts neuroprotective and anti-platelet aggregation effects. It has been shown to dilate cerebral blood vessels, increase cerebral blood flow, and inhibit ferroptosis, potentially through the activation of the AKT/Nrf2/HO-1 signaling pathway.

Brand names
Shu Nao Xin Di WanShu Nao Xin Dripping PillShunaoxin Dripping PillsShunaoxin Dropping Pills
Other names
SNXShunaoxinShunaoxin pills
02

Targets

CaV (Voltage-gated calcium channel protein complex)KOR (Kappa opioid receptor)SCN3B (Sodium channel beta-3 subunit)GABRP (GABA-A receptor subunit pi)PDK (Pyruvate dehydrogenase kinase isoform 1)MAPK14 (p38 mitogen-activated protein kinase alpha)GABRA5 (Gamma-aminobutyric acid type A receptor subunit alpha-5)

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