shuangqing granules

Shuangqing Granules (SQG) is a Traditional Chinese Medicine (TCM) formulation primarily investigated for the treatment of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome. The preparation is typically composed of four primary herbal extracts: *Semen Cassiae* (Cassia seed), *Fructus Crataegi* (Hawthorn), *Rhizoma Alismatis* (Alisma), and *Folium Nelumbinis* (Lotus leaf). SQG is designed to address the TCM patterns of phlegm-dampness and blood stasis, which correlate with lipid accumulation and metabolic dysfunction. Mechanistically, SQG has been shown to regulate lipid metabolism by activating the AMP-activated protein kinase (AMPK) signaling pathway and modulating peroxisome proliferator-activated receptors (PPARs), particularly PPAR-alpha. These actions lead to the downregulation of lipogenic transcription factors such as SREBP-1c and the reduction of hepatic fat accumulation. Clinical trials, primarily conducted at institutions like Longhua Hospital in China, have demonstrated its potential to reduce hepatic fat content (as measured by MRI-PDFF) and improve liver enzyme profiles in patients with NAFLD.

Other names

Shuang-Qing Granules