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shuangshen keli
- Development stage
- Unknown
- Lead developer
- Buchang Pharmaceuticals
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Shuangshen Keli is a Traditional Chinese Medicine (TCM) granule formulation primarily composed of extracts from *Panax ginseng* (Ren Shen) and *Salvia miltiorrhiza* (Dan Shen). Developed and manufactured by Shandong Buchang Pharmaceuticals, it is widely used in China for the treatment of cardiovascular diseases, including coronary heart disease, angina pectoris, and chronic heart failure. The formulation is designed to address the TCM syndrome of "Qi deficiency and blood stasis" by tonifying Qi, nourishing the heart, and promoting blood circulation. Clinical studies have demonstrated its ability to improve cardiac function, enhance myocardial microcirculation, and reduce inflammatory markers such as NT-proBNP and IL-6.
- Brand names
- Shuangshen Keli
- Other names
- Shuangshen granulesShuang-Shen-Ke-Li
02
Targets
NOS1 (nNOS)TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)
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