Drug intelligence / Profile preview

Shuangshi Tonglin capsules

Development stage
Unknown
Lead developer
Shaanxi Momentum Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Shuangshi Tonglin capsules is a Traditional Chinese Medicine (TCM) formulation used for the treatment of lower urinary tract irritation-related diseases, including chronic prostatitis, acute cystitis, and acute urethritis. The product is composed of several botanical extracts, such as *Pyrrosia lingua*, *Lygodium japonicum*, and *Phellodendron amurense*, which are traditionally used to clear heat, resolve dampness, and promote urination. It is clinically utilized in China to alleviate symptoms like frequent, urgent, and painful urination. Recent clinical evaluations include Phase 4 observational studies comparing its effectiveness and safety against Western treatments like saw palmetto extract or standard antibiotics.

Brand names
Shuangshi Tonglin capsules
Other names
Shuangshi Tonglin JiaonangShuang Shi Tong Lin Jiao Nang
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)VEGFA (Vascular endothelial growth factor A)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TGFB1 (Transforming growth factor Beta-1 proprotein)EGFR T790M (Epidermal growth factor receptor T790M mutant)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)

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