Drug intelligence / Profile preview

Shugan Hewei recipe

Development stage
Unknown
Lead developer
Beijing Hospital of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Shugan Hewei recipe (SHR) is a traditional Chinese medicine (TCM) herbal prescription developed by the Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University. It is primarily used for the treatment of gastroesophageal reflux disease (GERD) and its associated symptoms, including acid regurgitation, chest pain, and mood disturbances such as anxiety and depression. SHR is administered in granule form and contains active phytochemicals such as quercetin, kaempferol, and luteolin. Its mechanism of action involves the modulation of inflammatory and immune responses through targets like TGF-β1, IL-1β, IL-4, and various MAP kinases. Clinical studies have evaluated its efficacy in comparison to proton pump inhibitors like omeprazole.

Other names
Shugan Hewei formulaSGHW recipe
02

Targets

IL8 (C-X-C Motif Chemokine Ligand 8)TGFB1 (Transforming growth factor Beta-1 proprotein)IL-4 (Interleukin 4)FOS (Activator Protein 1)IL1B (Interleukin-1 beta)IL10 (Interleukin-10)CXCL10 (C-X-C Motif Chemokine Ligand 10)MAPK3 (Mitogen-activated protein kinase 1)IL-2 (Interleukin 2)

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