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Shugan Jianpi Granules
- Development stage
- Unknown
- Lead developer
- KPC Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Shugan Jianpi Granules is an oral Traditional Chinese Medicine (TCM) formulation produced by several manufacturers, including Beijing Tcmages Pharmaceutical, Chongqing Peidu Pharmaceutical, Jiangsu Kangyuan Pharmaceutical, and Guangdong Zongsheng Pharmaceutical. Based on TCM principles, the drug is designed to soothe the liver, invigorate the spleen, and harmonize the stomach, specifically targeting 'liver qi stagnation' and 'spleen deficiency'. The formulation contains a blend of herbal ingredients, notably Radix astragali (Huang Qi), Radix bupleuri (Chai Hu), and Radix angelicae alba (Dang Gui). It is primarily indicated for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D), cancer-related fatigue in breast cancer patients, functional dyspepsia, and nonalcoholic steatohepatitis (NASH). Clinical evidence suggests that the granules improve symptoms such as abdominal pain and fatigue, with a mechanism of action in IBS-D that may involve the reduction of serotonin-positive cells in the gut mucosa. Additionally, a related formulation (Shugan Jianpi plaster) has been studied for chronic hepatitis B.
- Brand names
- Shu Gan Jian Pi granulesShu Gan Jian Pi formulaSGJP
- Other names
- Shugan Jianpi Keli疏肝健脾颗粒
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)
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