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shugan jieyu (Lunan Houpu Pharmaceutical Co., Ltd.)
- Development stage
- Unknown
- Lead developer
- Chengdu Kanghong Pharmaceutical
- Administration
- Oral
01
Overview
Shugan Jieyu is a standardized Traditional Chinese Medicine (TCM) formulation primarily indicated for the treatment of mild to moderate depression. It is a botanical combination product consisting of two main active herbal extracts: *Hypericum perforatum* (St. John's Wort) and *Acanthopanax senticosus* (Siberian Ginseng). The therapeutic efficacy of Shugan Jieyu is attributed to the synergistic effects of its components, particularly the reuptake inhibition of monoamine neurotransmitters such as serotonin, norepinephrine, and dopamine by St. John's Wort, combined with the adaptogenic and neuroprotective properties of *Acanthopanax senticosus*. Developed and manufactured by Lunan Hope Pharmaceutical, it has been extensively studied in clinical trials as an alternative or adjunct to conventional selective serotonin reuptake inhibitors (SSRIs) like fluoxetine, demonstrating comparable efficacy with a potentially more favorable safety profile regarding side effects like sexual dysfunction and weight gain.
- Brand names
- Shugan Jieyu Capsule
- Other names
- Shugan JieyuShugan Jieyu Jiaonang
02
Targets
SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)DAT (Dopamine plasma membrane transport protein)
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