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Shugan Jieyu Particles
- Development stage
- Unknown
- Lead developer
- Southern Medical University
- Administration
- Oral
01
Overview
Shugan Jieyu Particles is a Traditional Chinese Medicine (TCM) formulation primarily indicated for the treatment of major depressive disorder. It is composed of herbal ingredients, notably *Hypericum perforatum* (St. John's Wort) and *Acanthopanax senticosus* (Siberian Ginseng/Eleuthero). The drug is considered a pure herbal pharmaceutical product and a Chinese patent medicine. Its therapeutic effects are mediated through multiple mechanisms, including the modulation of neurotransmitter reuptake and monoamine oxidase activity, as well as influencing inflammatory pathways and neurotrophic factors.
- Other names
- 疏肝解郁颗粒Shugan Jieyu KeliShugan Jieyu CapsuleSGJY
02
Targets
IL1B (Interleukin-1 beta)MAPK3 (Mitogen-activated protein kinase 1)NET (Norepinephrine Transporter)JUN (Transcription factor Jun)SERT (Sodium-dependent serotonin transporter)VEGFA (Vascular endothelial growth factor A)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)DAT (Dopamine plasma membrane transport protein)MAOA (Monoamine oxidase A)IL-6 (Interleukin 6)CASP3 (Caspase-3)
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