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Shuganning injection
- Development stage
- Phase 4
- Lead developer
- Guizhou Ruihe Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Shuganning injection is a traditional Chinese medicine injection widely used in China for the treatment of liver and gallbladder diseases, including acute and chronic viral hepatitis, drug-induced liver injury, and jaundice. It is formulated from the extracts of five traditional Chinese medicinal herbs: *Artemisia capillaris* (Yinchen), *Gardenia jasminoides* (Zhizi), *Isatis indigotica* (Banlangen), *Ganoderma lucidum* (Lingzhi), and baicalin (extracted from *Scutellaria baicalensis* / Huangqin). The injection exerts hepatoprotective, anti-inflammatory, antioxidant, and anti-apoptotic effects, helping to reduce liver injury, promote bile secretion, and alleviate jaundice.
- Other names
- SGNIShu Gan Ning injectionShuganning Zhusheye舒肝宁注射液
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)BAX (Apoptosis regulator BAX)CASP3 (Caspase-3)HSP90AA1 (Heat shock protein HSP90-alpha)MAPK14 (p38 mitogen-activated protein kinase alpha)MRGPRX2 (Mas-related G-protein Coupled Receptor X2)TP53 (Cellular Tumor Antigen p53 R175H)
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