Drug intelligence / Profile preview

Shujin Xiaotong capsule

Development stage
Preclinical
Lead developer
The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Shujin Xiaotong capsule is a Traditional Chinese Medicine (TCM) preparation used for treating knee osteoarthritis, rheumatic bone pain, and related musculoskeletal conditions. The formulation is composed of six herbal ingredients: *Ligusticum wallichii* (Chuanxiong), *Angelica pubescens* (Duhuo), *Angelica sinensis* (Danggui), *Taxillus chinensis* (Sangjisheng), *Spatholobus suberectus* (Jixueteng), and *Dipsacus asper* (Xuduan). It functions by targeting inflammatory pathways, specifically inhibiting tumor necrosis factor-alpha (TNF-α) and the phosphorylation of nuclear factor kappa B (NF-κB). Research indicates that ligustrazine, a bioactive component from *Ligusticum wallichii*, plays a significant role in inhibiting chondrocyte apoptosis and reducing inflammatory markers, thereby facilitating articular cartilage repair and improving joint function.

Brand names
Shujin Xiaotong capsule
Other names
Shujin Xiaotong jiaonang
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))NF-κB

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