Drug intelligence / Profile preview

Shumu Decoction + sodium hyaluronate

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Intraarticular, Topical
01

Overview

Shumu Decoction + sodium hyaluronate is a combination therapy consisting of a traditional Chinese medicine (TCM) herbal formula, "Shumu Decoction," and the pharmaceutical agent sodium hyaluronate. Sodium hyaluronate is a naturally occurring glycosaminoglycan used as an intra-articular injection or topical agent to relieve pain in osteoarthritis and promote wound healing by acting as a lubricant and shock absorber in joints or as a moisture-retaining agent on skin[1][3][4][5]. Shumu Decoction refers to an herbal blend from TCM, but its precise composition is not standardized in Western literature; similar decoctions are typically used for blood nourishment, circulation improvement, or other systemic effects depending on the specific herbs included[8]. The combination aims to leverage both the symptomatic relief provided by sodium hyaluronate and the systemic or supportive effects attributed to TCM herbal therapy.

02

Targets

ICAM1 (Intercellular Adhesion Molecule 1)RHAMM (Hyaluronan-mediated motility receptor)LYVE1 (Lymphatic vessel endothelial hyaluronic acid receptor 1)STAB2 (Stabilin-2)CD44 (CD44 antigen)

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