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Shunqi Tongxie Granules is a Traditional Chinese Medicine (TCM) formulation developed by the Xi'an Shangyikang Pharmaceutical Research Institute for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D). The drug is designed based on the TCM principles of soothing the liver, strengthening the spleen, and regulating qi to alleviate symptoms such as abdominal pain, bloating, and frequent diarrhea. It is specifically indicated for patients presenting with the 'liver depression and spleen deficiency' syndrome. The formulation has undergone Phase 2 and Phase 3 clinical trials in China, where it was evaluated for its ability to improve stool consistency and reduce abdominal discomfort compared to placebo. As a complex herbal mixture, it likely exerts its therapeutic effects through multiple mechanisms, including the regulation of gut motility and visceral hypersensitivity via the brain-gut axis.
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