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shVDR-EPCs
- Development stage
- Preclinical
- Modality
- Gene Therapies, Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
shVDR-EPCs are genetically modified endothelial progenitor cells (EPCs) engineered to overexpress the vitamin D receptor (VDR). This cell-based therapy is being investigated for its potential in angiogenic therapies, particularly for inhibiting atherosclerosis. The overexpression of VDR in these EPCs has been shown to reduce atherosclerotic plaque formation, improve lipid profiles by increasing serum HDL-C and decreasing total cholesterol, LDL-C, apoB, and Lp(a). Additionally, shVDR-EPCs enhance endothelial function by improving serum nitric oxide (NO) concentration and elevating endothelial nitric oxide synthase (eNOS) expression. They also modulate extracellular matrix remodeling by reducing the expression and activity of matrix metalloproteinase 2 (MMP2) and elevating the expression and activity of tissue inhibitor of metalloproteinases 2 (TIMP2).
- Other names
- ovVDR-EPCsEPCs that overexpress vitamin D receptor
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