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shWTAP
- Development stage
- Preclinical
- Lead developer
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
shWTAP is an experimental short hairpin RNA (shRNA) designed to silence the expression of Wilms' tumor 1-associating protein (WTAP). WTAP is a key component of the m6A methyltransferase complex and is frequently upregulated in various cancers, including glioblastoma multiforme (GBM). By knocking down WTAP, shWTAP inhibits cancer cell proliferation and reduces stem-cell-like properties (stemness) in patient-derived cancer stem cells. Research indicates that WTAP plays a role in post-transcriptional regulation by decreasing intron retention and increasing exon skipping. shWTAP serves as a research tool to investigate the oncogenic role of WTAP and its potential as a therapeutic target in oncology.
- Other names
- WTAP-targeting shRNAshort hairpin RNA targeting WTAP
02
Targets
WTAP (Pre-mRNA-splicing regulator WTAP)
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