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si-IGFBP4
- Development stage
- Preclinical
- Lead developer
- University of California, San Francisco
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravitreal
01
Overview
si-IGFBP4 is a small interfering RNA (siRNA) designed to silence the expression of Insulin-like growth factor-binding protein 4 (IGFBP-4). It is primarily utilized as a research tool to investigate the functional role of IGFBP-4 in various biological contexts, particularly in cancer progression. In studies involving renal cell carcinoma (RCC), si-IGFBP4 has been used to knock down IGFBP-4 mRNA in metastatic cell lines, such as ACHN, resulting in significantly decreased cell growth and motility. These findings suggest that IGFBP-4 may act as an oncogenic driver in RCC by activating the Wnt/beta-catenin signaling pathway and inducing markers of tumor progression like M-CAM, contrasting with its known role as a Wnt antagonist in other tissues.
- Other names
- IGFBP-4 siRNAIGFBP4 siRNAIGFBP 4 siRNAsiRNA targeting IGFBP-4
02
Targets
IGFBP4 (Insulin-like growth factor-binding protein 4 (IGFBP4) mRNA)
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