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si jun zi tang
- Development stage
- Phase 4
- Administration
- Oral
01
Overview
Si Jun Zi Tang is a classic traditional Chinese medicine (TCM) herbal formula known as the Four Gentlemen Decoction. It consists of four main herbs—ginseng (Ren Shen), atractylodes (Bai Zhu), poria (Fu Ling), and licorice root (Zhi Gan Cao or Gan Cao)—and is designed to tonify qi and strengthen the spleen and stomach. The formula is primarily used for symptoms associated with spleen qi deficiency, such as fatigue, poor appetite, loose stools, pale complexion, and general weakness. Its mechanism of action in TCM involves supporting digestive function and nutrient absorption by enhancing the body's ability to convert food into energy and vital substances. Modern uses include support for chronic fatigue syndrome, digestive disorders like gastritis or irritable bowel syndrome, immune system enhancement during recovery from illness or chemotherapy-induced weakness[1][3][4][6]. Si Jun Zi Tang serves as a foundational tonic in TCM practice.
- Brand names
- Sijunzi decoctionSJZD granules
- Other names
- four gentlemen decoction四君子汤si jun zi tang
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)IL-6 (Interleukin 6)JUN (Transcription factor Jun)MAPK14 (p38 mitogen-activated protein kinase alpha)MAPK3 (Mitogen-activated protein kinase 1)RELA (Nuclear Factor Kappa B Subunit p65)STAT3 (Signal Transducer and Activator of Transcription 3)TP53 (Cellular Tumor Antigen p53 R175H)
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