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si-KITENIN
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Transfection
01
Overview
si-KITENIN is a small interfering RNA (siRNA) designed to silence expression of the KITENIN gene, which encodes the KAI1 COOH-terminal interacting tetraspanin protein. KITENIN is implicated in tumor progression and metastasis, particularly in colorectal cancer and head and neck squamous cell carcinoma. By introducing si-KITENIN into cancer cells, KITENIN expression is suppressed at the mRNA level via RNA interference, resulting in decreased cell invasion, migration, and proliferation. si-KITENIN has been evaluated in preclinical models using transfection/intravenous delivery and demonstrated significant anti-tumor effects, including reduced metastasis and tumor burden[2][6].
- Other names
- small interfering RNA targeting KITENINanti-KITENIN siRNA
02
Targets
VANGL1 (VANGL planar cell polarity protein 1)
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