si-LINC01291

si-LINC01291 is a small interfering RNA (siRNA) designed to silence the expression of the long intergenic non-protein coding RNA 1291 (LINC01291). In melanoma research, LINC01291 has been identified as an oncogenic long noncoding RNA (lncRNA) that promotes tumor progression by acting as a competing endogenous RNA (ceRNA). It sponges microRNA-625-5p (miR-625-5p), which normally targets and suppresses the insulin-like growth factor 1 receptor (IGF-1R). By silencing LINC01291, si-LINC01291 restores miR-625-5p activity, leading to the downregulation of IGF-1R expression. This intervention has been shown to inhibit cell proliferation, migration, and invasion, while inducing apoptosis and increasing the sensitivity of melanoma cells to cisplatin in preclinical models.

Other names

LINC01291 siRNALINC-01291 siRNALINC 01291 siRNAsmall interfering RNA targeting LINC01291