Drug intelligence / Profile preview

Si Miao Xiao Ling Zhi Wang Tang

Development stage
Preclinical
Administration
Oral
01

Overview

Si Miao Xiao Ling Zhi Wang Tang (四妙效灵治尪汤) is a traditional Chinese medicine formula. The name suggests it is a compound prescription, likely based on or related to classic formulas such as "Si Miao San" (Four Marvels Powder) and other "Zhi Wang Tang" (treating 'Wang' syndrome, which refers to chronic joint diseases in TCM). However, there is no direct evidence in the provided sources that this exact formula—under this full name—is widely recognized or standardized in major TCM pharmacopeias. The closest related formulas are "Si Miao Yong An Tang" and "Si Miao San," both used for clearing heat, resolving dampness, and treating inflammatory conditions such as rheumatoid arthritis and gout[2][5][7]. These formulas typically contain herbs like Cang Zhu (Atractylodes), Niu Xi (Achyranthes), Huang Bai (Phellodendron), Yi Yi Ren (Coix seed), Jin Yin Hua (Lonicera), Xuan Shen (Scrophularia), Dang Gui (Angelica sinensis), and Gan Cao (Glycyrrhiza). Their mechanisms involve anti-inflammatory effects, immune modulation, improving microcirculation, clearing heat-toxins, dispelling wind-dampness, and relieving pain[2][5]. The term “Zhi Wang” indicates use for chronic rheumatic conditions with symptoms of joint swelling/pain/stiffness. Such formulas are often used orally under professional supervision for rheumatoid arthritis or similar syndromes characterized by damp-heat or cold-damp obstruction according to TCM theory.

Other names
四妙效灵治尪汤
02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)IL-6 (Interleukin 6)MMP9 (Matrix metalloproteinase-9)VEGFA (Vascular endothelial growth factor A)

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