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si-MIR4435-2HG

Development stage: Preclinical
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Injection

Overview

si-MIR4435-2HG is an experimental small interfering RNA (siRNA) designed to silence the long non-coding RNA (lncRNA) MIR4435-2HG. In hepatocellular carcinoma (HCC), MIR4435-2HG acts as a competitive endogenous RNA (ceRNA) that sponges miR-29c-3p, which normally suppresses the expression of Ferroptosis Suppressor Protein 1 (FSP1). By silencing MIR4435-2HG, this siRNA restores miR-29c-3p activity, leading to the downregulation of FSP1 and the subsequent induction of ferroptosis. This mechanism has been shown to overcome lenvatinib resistance in HCC cells, suggesting its potential as a therapeutic strategy for advanced liver cancer.

Other names: MIR4435-2HG siRNAMIR-4435-2HG siRNAMIR 4435-2HG siRNAsiRNA targeting MIR4435-2HG

Targets

MIR4435-2HG (MIR4435-2 host gene)

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