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si ni san + xiao chai hu tang
- Development stage
- Unknown
- Lead developer
- Henry Liang Clinic
- Administration
- Oral
01
Overview
Si Ni San + Xiao Chai Hu Tang is a combination of two classical Chinese herbal formulas (CHM) used in traditional medicine and recently reported as a maintenance therapy for breast cancer. Si Ni San (SNS) typically comprises *Bupleurum chinense*, *Paeonia lactiflora*, *Citrus aurantium*, and *Glycyrrhiza uralensis*, and is traditionally used to soothe the liver and regulate Qi, which may help manage psychological stress. Xiao Chai Hu Tang (XCT) consists of *Bupleurum chinense*, *Scutellaria baicalensis*, *Codonopsis pilosula*, *Glycyrrhiza uralensis*, *Pinellia ternata*, *Zingiber officinale*, and *Ziziphus jujuba*. XCT has demonstrated anti-tumor activities including growth inhibition, apoptosis induction, and immune enhancement. In clinical case reports, this combination is often supplemented with other anti-cancer herbs such as *Rabdosia rubescens*, *Prunella vulgaris*, and *Hedyotis diffusa* to target pathways like PI3K/AKT, NF-κB, and VEGF/HIF-1α.
- Other names
- SNS + XCTSini San + Xiao Chaihu TangXiao Chai Hu Tang + Si Ni San
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)HIF1A (Hypoxia-inducible factor 1-alpha)MAPK3 (Mitogen-activated protein kinase 1)NF-κBPI3K (Phosphoinositide-3-kinase regulatory subunit 6)VEGFA (Vascular endothelial growth factor A)HSPA5 (Heat shock protein family A member 5)AKT (RAC-alpha serine/threonine-protein kinase)ALOX5 (Arachidonate 5-lipoxygenase)MEK
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