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si-OIP5-AS1

Development stage: Preclinical
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intratumoral

Overview

si-OIP5-AS1 is an experimental small interfering RNA (siRNA) designed to silence the long non-coding RNA (lncRNA) OIP5 antisense RNA 1 (OIP5-AS1). In glioblastoma (GBM) research, OIP5-AS1 has been identified as an oncogenic factor that promotes tumor progression and mediates resistance to the standard chemotherapeutic agent temozolomide. The mechanism of si-OIP5-AS1 involves the targeted degradation of OIP5-AS1 transcripts, which subsequently leads to the upregulation of microRNA-129-5p (miR-129-5p). This increase in miR-129-5p levels results in the downregulation of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), thereby inhibiting tumor cell proliferation and restoring sensitivity to temozolomide in glioblastoma cells.

Other names: OIP5-AS1 siRNAOIP-5-AS1 siRNAOIP 5-AS1 siRNAsiRNA targeting OIP5-AS1

Targets

OIP5-AS1 (OIP5 antisense RNA 1)

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