Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
si-PMEPA1
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Inhalation
01
Overview
si-PMEPA1 is a small interfering RNA (siRNA) designed to silence the expression of the Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1), also known as TMEPAI. PMEPA1 is a transmembrane protein that plays a critical role in regulating the TGF-β signaling pathway and maintaining mitochondrial homeostasis. In the context of chronic respiratory conditions such as asthma, si-PMEPA1 is utilized in preclinical research to investigate the therapeutic potential of knocking down PMEPA1 to reverse airway remodeling and restore airway structural cell homeostasis. By specifically targeting PMEPA1 mRNA for degradation, this siRNA aims to mitigate mitochondrial damage and modulate mitophagy, addressing key drivers of asthma progression and therapeutic resistance.
- Other names
- PMEPA1 siRNAPMEPA-1 siRNAPMEPA 1 siRNAsiRNA targeting PMEPA1TMEPAI siRNA
02
Targets
PMEPA1 (Prostate transmembrane protein, androgen induced 1)
Beyond the preview
Go deeper on si-PMEPA1.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on si-PMEPA1.