Si Shen

Si Shen, also known as Si Shen Wan, Si Shen Pills, or Si Shen Decoction, and available in granule form (四神颗粒剂), is a traditional Chinese medicine (TCM) formula. It is primarily used to treat gastrointestinal disorders such as diarrhea-predominant Irritable Bowel Syndrome (IBS-D), chronic colitis, ulcerative colitis, and daybreak diarrhea, by warming and tonifying the Spleen and Kidneys, astringing the intestines, and stopping diarrhea. It also demonstrates therapeutic potential in inflammatory conditions like Collagen-induced Arthritis (CIA) or Rheumatoid Arthritis (RA). Its mechanisms involve inhibiting apoptosis of intestinal epithelial cells, modulating inflammatory pathways (e.g., PI3K/Akt, p38 MAPK, FABP4/PPARγ/NFκB), regulating gut microbiota, and influencing various cytokine expressions.

Brand names

Sishen Keli

Other names

Si Shen WanSi Shen PillsSi Shen Decoction四神颗粒剂四神丸四神汤Four Miracle PillFour Divinity PillPsoralia and Myristica FormulaPsoralia and Myristica Combination