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si-SOX21-AS1

Development stage: Preclinical
Lead developer: University of Virginia
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intravenous

Overview

si-SOX21-AS1 is a small interfering RNA (siRNA) designed to target and knock down the expression of the long non-coding RNA (lncRNA) **SOX21-AS1**. In the context of glioblastoma (GBM) research, SOX21-AS1 has been identified as a downstream target of gain-of-function mutant p53 (MUT-p53). Studies have shown that MUT-p53 binds to the promoter of SOX21-AS1, leading to its upregulation and subsequent oncogenic effects. The use of si-SOX21-AS1 to silence this lncRNA has been demonstrated to induce significant cell death in GBM cell lines, suggesting that SOX21-AS1 plays a critical role in tumor cell survival and may serve as a potential therapeutic target in p53-mutant glioblastoma.

Other names: SOX21-AS1 siRNASOX-21-AS1 siRNASOX 21-AS1 siRNAsiRNA targeting SOX21-AS1

Targets

SOX21-AS1 (SOX21 antisense RNA 1)

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