Drug intelligence / Profile preview

Si Wu Tang

Development stage
Phase 3
Modality
Drug Delivery Systems
Administration
Oral
01

Overview

Si Wu Tang, also known as Four Substances Decoction, is a traditional Chinese medicine formula composed of four herbs: Rehmannia (Shu Di Huang), Angelica (Dang Gui), Peony (Bai Shao), and Ligusticum (Chuan Xiong). This herbal combination has been used for centuries in Chinese medicine, particularly for treating blood deficiency conditions and gynecological disorders. ## Composition and Preparation The original formula of Si Wu Tang consists of: - 12g Shu Di Huang (Rehmannia) - 9g Dang Gui (Angelica Sinensis) - 9g Bai Shao (Paeonia) - 6g Chuan Xiong (Ligusticum) These herbs work synergistically, with Shu Di Huang and Bai Shao functioning as the principal ingredients that tonify blood, while Dang Gui and Chuan Xiong regulate blood circulation to prevent stagnation. ## Therapeutic Actions and Uses Si Wu Tang is primarily known for: - **Blood Tonification**: It's considered the representative formula for tonifying blood in traditional Chinese medicine. - **Menstrual Health**: Often used for menstrual discomfort, dysmenorrhea, amenorrhea, and climacteric syndrome. - **Blood Deficiency Conditions**: Addresses symptoms like pale complexion, dry skin, poor sleep, lightheadedness, and lack of energy. - **Reproductive Health**: Used for threatened abortion and infertility. - **Skin Conditions**: Helps with chronic itching, dermatitis, atopic dermatitis, and urticaria. - **Other Conditions**: May be used for insomnia, chronic nephritis, and anemia. ## Pharmacological Effects Research has demonstrated several pharmacological effects of Si Wu Tang: - Hematopoietic (blood-forming) effects - Radioprotective properties - Anti-pruritic (anti-itching) effects - Anti-inflammatory actions - Anti-neoplastic (anti-cancer) properties - Antioxidant effects - Positive regulation of lipid profiles and liver function - Improvement of skin integrity and texture ## Traditional Use and Historical Significance Si Wu Tang has been called "the first prescription for gynecology" and "the holy medicine for women" for its ability to tonify and regulate blood. It has a long history in Chinese medicine, appearing in classical texts and being widely used by practitioners throughout history, including notable female physicians like Dr. Tan during the Song dynasty. ## Precautions Si Wu Tang should be used with caution in individuals with deficiency of the Spleen and Stomach, as the rich, stagnating nature of Shu Di Huang could affect digestion. It's often recommended to use spleen tonics concurrently when administering this formula. It should be avoided in individuals with dampness or Qi deficiency without modification, as it can cause vomiting.

Brand names
Si Wu TangFour-Substance Decoction四物汤
Other names
Four Substances Decoction
02

Targets

ESR1 (ERα)

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