siATP5G3

siATP5G3 is a small interfering RNA (siRNA) that targets the mRNA of the ATP5G3 gene, which encodes subunit C3 of the mitochondrial ATP synthase complex (Complex V). By silencing ATP5G3 expression, this agent is used in research to investigate mitochondrial function and cell death pathways. In cervical carcinoma (HeLa) cell models, siATP5G3-mediated knockdown has been shown to enhance cytotoxicity induced by sodium nitroprusside (SNP). This effect is mediated through the activation of the p38 MAPK signaling pathway and the subsequent modulation of pro-apoptotic and anti-apoptotic proteins like Bax and Bcl-xL, leading to autophagic or lysosome-associated cell death. It serves as a research tool to demonstrate the protective role of ATP5G3 against oxidative stress-induced cell death.

Other names

ATP5G3 siRNAATP-5G3 siRNAATP 5G3 siRNAsmall interfering RNA targeting ATP5G3