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SIBP-A19
- Development stage
- Phase 1
- Lead developer
- Shanghai Institute of Biological Products
- Modality
- Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
SIBP-A19 is an **antibody-drug conjugate (ADC)** under development for the treatment of advanced solid tumors, including malignant solid neoplasms, endometrial carcinoma, and non-small cell lung cancer. It is designed to target **folate receptor alpha (FOLR1)** on cancer cells, acting as an antagonist, and delivers a payload that inhibits **DNA topoisomerase I (TOP1)**, thereby preventing DNA replication and inducing tumor cell death. The drug is being developed by the Shanghai Institute of Biological Products and is currently in phase 1 clinical trials aimed at establishing safety, tolerability, pharmacokinetics, and determining the maximum tolerated dose[2][3][5].
- Brand names
- SIBP-A19SIBP-A-19SIBP-A 19
- Other names
- SIBP-A19SIBP-A-19SIBP-A 19
02
Targets
TOP1 (DNA Topoisomerase I)FOLR1 (FRα)
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