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siCaveolin-1
- Development stage
- Preclinical
- Lead developer
- Kumamoto University
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
siCaveolin-1 is a small interfering RNA (siRNA) designed to silence the expression of the Caveolin-1 (CAV1) gene. Caveolin-1 is a key structural component of caveolae and has been implicated in various signaling pathways, including those governing cellular senescence and cancer progression. In pancreatic cancer research, siCaveolin-1 is used to knockdown CAV1 in cancer-associated fibroblasts (CAFs) to study its impact on the tumor microenvironment. Experimental evidence suggests that high Caveolin-1 expression in CAFs correlates with poor patient prognosis and increased tumor cell invasion; silencing CAV1 with siCaveolin-1 has been shown to reduce the invasive potential of pancreatic cancer cells in co-culture models.
- Other names
- Caveolin-1 siRNACaveolin1 siRNACaveolin 1 siRNAsi-CAV1si-CAV-1si-CAV 1
02
Targets
CAV1 (Caveolin-1)
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