Drug intelligence / Profile preview

sichuan dark tea

Development stage
Preclinical
Administration
Oral
01

Overview

Sichuan dark tea is a traditional post-fermented tea produced from Camellia sinensis leaves in Sichuan province, China, particularly known as Ya'an South-road Dark Tea (SSDT) or Zangcha. It undergoes a unique microbial solid-state fermentation, resulting in characteristic flavors, colors, and bioactive chemical composition. Rich in polyphenols, catechins, amino acids, caffeine, and unique metabolites, Sichuan dark tea has reported biological activities including lowering blood lipids, improving lipid metabolism, modulating gut microbiota, exhibiting anti-hyperglycemic, antihypertensive, anti-atherogenic and possible anti-obesity effects. Mechanistically, its effects are attributed to modulation of metabolic and regulatory pathways such as AMPK activation, increased HDL, reduced triglycerides, increased expression of cholesterol efflux proteins (ABCA1), activation of fatty acid oxidation genes (PPARα, PPARγ, LXRα), and gut microbiota modulation. It is used both as a beverage and in traditional medicine for prevention and adjunct management of metabolic and cardiovascular diseases[1][2][4][5][7][8].

Other names
ya'an south-road dark teaSSDTzangchasichuan south-road dark teaya'an tibetan tea
02

Targets

ABCA1 (ATP-binding cassette transporter A1)AMPK (Adenosine monophosphate–activated protein kinase)PPARG (Peroxisome proliferator-activated receptor gamma)LIPE (Hormone-sensitive lipase)PPARA (Peroxisome proliferator-activated receptor alpha)LPL (Lipoprotein lipase)NR1H3 (Liver X receptor beta)

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