Drug intelligence / Profile preview

Sichuan Univ. AHR compound 24e

Development stage
Preclinical
Lead developer
Sichuan University
01

Overview

Sichuan Univ. AHR compound 24e: sourced facts only. name: "Structure-activity relationship analyses led to the identification of the most active compound, 5- ((1H-indazol-3-yl)methylene) -3- (prop-2-yn-1-yl) -2-thiooimidazolidin-4-one (24e), which exhibited an EC50 value of 0.015 µM against AHR." [PMID:37348572]; target: "Structure-activity relationship analyses led to the identification of the most active compound, 5- ((1H-indazol-3-yl)methylene) -3- (prop-2-yn-1-yl) -2-thiooimidazolidin-4-one (24e), which exhibited an EC50 value of 0.015 µM against AHR." [PMID:37348572]; developer: "Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China." [PMID:37348572]; stage: "Topical administration of 24e substantially alleviated imiquimod (IMQ)-induced psoriasis-like skin lesion." [PMID:37348572]

02

Targets

AHR (Aryl hydrocarbon receptor)

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