Drug intelligence / Profile preview

Sichuan Univ. SIRT5 compound 8

Development stage
Unknown
Lead developer
Sichuan University
01

Overview

Sichuan Univ. SIRT5 compound 8: sourced facts only. name: "These ε-N-thioglutaryllysine derivatives displayed potent SIRT5 inhibition, of which the potential photo-crosslinking derivative 8 manifested most potent inhibition with an IC50 value of 120 nM to SIRT5, and low inhibition to SIRT1-3 and SIRT6." [PMID:36996510]; target: "These ε-N-thioglutaryllysine derivatives displayed potent SIRT5 inhibition, of which the potential photo-crosslinking derivative 8 manifested most potent inhibition with an IC50 value of 120 nM to SIRT5, and low inhibition to SIRT1-3 and SIRT6." [PMID:36996510]; developer: "Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China." [PMID:36996510]

02

Targets

SIRT5 (NAD-dependent protein deacylase sirtuin-5, mitochondrial)

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