Drug intelligence / Profile preview

Sichuan Univ. tau aggregates compound 28

Development stage
Unknown
Lead developer
Sichuan University
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
01

Overview

Sichuan Univ. tau aggregates compound 28: sourced facts only. name: "Structure activity relationship study of these compounds led to the discovery of compound 28, which showed high affinity with tau aggregates (Ki = 0.99 nM)." [PMID:41512538]; target: "Structure activity relationship study of these compounds led to the discovery of compound 28, which showed high affinity with tau aggregates (Ki = 0.99 nM)." [PMID:41512538]; developer: "Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China." [PMID:41512538]; modality: "Therefore, the preclinical results revealed compound 28 holds the potential to be developed as a potent and selective tau aggregate targeted PET tracer, and further optimizations and evaluations may still be needed." [PMID:41512538]

02

Targets

aggregated p-tau (Microtubule-associated protein tau (aggregated/paired helical filament form))

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