Sichuan Univ. ULK1 compound 12i

Sichuan Univ. ULK1 compound 12i: sourced facts only. name: "Notably, compound 12i was synthesized and validated to form covalent bonds with ULK1, exhibiting pronounced selectivity and potent inhibitory activity (ULK1 IC50 = 4.7 μM)." [PMID:41672028]; target: "Notably, compound 12i was synthesized and validated to form covalent bonds with ULK1, exhibiting pronounced selectivity and potent inhibitory activity (ULK1 IC50 = 4.7 μM)." [PMID:41672028]; developer: "Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China." [PMID:41672028]; stage: "Additionally, in vivo results showed that 12i also exhibited good tumor inhibitory activity in CRC murine models, with an inhibition rate of 70.4 % at 40 mg/kg." [PMID:41672028]