siCPT1A

siCPT1A is a **small interfering RNA (siRNA)** designed to specifically silence the expression of the *carnitine palmitoyltransferase 1A (CPT1A)* gene. CPT1A is an enzyme critical for mitochondrial fatty acid oxidation, highly expressed in metabolically active tissues like liver and in certain cancer cell contexts. siCPT1A functions by promoting the degradation of CPT1A mRNA, thus reducing protein production. Research using siCPT1A has shown that **inhibiting CPT1A sensitizes cancer cells to chemotherapy, suppresses cancer stem cell stemness, and reduces the activation of hepatic stellate cells implicated in fibrosis**. These findings suggest that siCPT1A, as a molecular research tool or experimental therapeutic, has potential utility in diseases involving CPT1A overactivity—particularly in oncology (ovarian cancer, liver cancer) and fibrotic disorders[1][2].

Other names

small interfering RNA targeting CPT1A