Drug intelligence / Profile preview

Sida cordifolia

Development stage
Unknown
Modality
Drug Delivery Systems
Administration
Oral
01

Overview

Sida cordifolia, commonly known as Bala in Ayurvedic medicine, is a medicinal plant with a long history of traditional use. It contains various bioactive compounds including alkaloids like ephedrine and pseudoephedrine, which contribute to its pharmacological effects. The plant has been used in traditional Ayurvedic medicine for treating various conditions including inflammation, respiratory issues, and as a general tonic. Modern research has investigated its anti-inflammatory, analgesic, antioxidant, and adaptogenic properties. Sida cordifolia contains a small amount of ephedrine (0.8-1.2%), which has led to regulatory concerns in some countries. The US FDA banned products containing ephedrine, including Sida cordifolia, in 2004 due to potential cardiovascular side effects[5]. ## Traditional Uses Sida cordifolia has been traditionally used for: * Bronchial asthma and respiratory conditions * Inflammation and pain relief * Improving strength and stamina * Nervous system support * Joint and muscle pain * Fatigue and weakness ## Pharmacological Properties Research has demonstrated several pharmacological activities: * Anti-inflammatory and analgesic effects * Antioxidant properties * Adaptogenic and anti-stress effects * Immunomodulatory activity * Potential benefits for nervous system disorders ## Dosage and Administration The recommended dosage forms include: * **Powder:** 1/4-1/2 teaspoon twice daily (3-6 grams per day in divided doses) * **Capsules:** 1-2 capsules twice daily * **Juice:** 1-2 teaspoons once or twice daily (10-20 ml per day in divided doses) * **Decoction:** 50-100 ml in divided doses per day[1][3] Powder and capsules are typically taken after meals, with the powder mixed with milk or honey. The juice is usually diluted with water and consumed before meals[1]. ## Side Effects and Safety Concerns Due to its ephedrine content, excessive use may cause: * Insomnia and nervousness * Increased blood pressure * Memory issues * Cardiovascular concerns * Potential interactions with cardiac glycosides, monoamine oxidase inhibitors, and ergot alkaloids[1][2][3] The ephedrine content in Sida cordifolia is relatively low (0.8-1.2%), but regulatory authorities in some countries have restricted its use due to safety concerns[5].

Other names
Bala
02

Targets

BCL-2 (BCL-2 family)

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