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siFAM17
- Development stage
- Preclinical
- Lead developer
- The First Affiliated Hospital of USTC
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
siFAM17 is a GalNAc-conjugated small interfering RNA (siRNA) designed to target and silence the expression of FAM17 [4373]. FAM17 acts as a suppressor of senescence-associated transcription in hepatocellular carcinoma (HCC) by interacting with PHF and promoting its degradation, which restrains PHF-dependent RNA polymerase II (Pol II) pause release and transcriptional elongation [4373]. Silencing FAM17 with siFAM17 promotes tumor cell senescence, activates the senescence-associated secretory phenotype (SASP), remodels the tumor immune microenvironment (increasing NK-cell infiltration and reducing myeloid-cell abundance), and suppresses liver tumorigenesis [4373].
- Other names
- GalNAc-conjugated siFAM17GalNAc-siFAM17GalNAc-siFAM-17GalNAc-siFAM 17
02
Targets
FAM107A
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