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siFibrinogen
- Development stage
- Preclinical
- Lead developer
- SeraGene Therapeutics
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
siFibrinogen (SG-002) is a preclinical-stage lipid nanoparticle (LNP)-formulated small interfering RNA (siRNA) therapeutic developed by SeraGene Therapeutics. It specifically targets the mRNA of the fibrinogen alpha chain (FGA) in the liver, enabling a precise, reversible reduction of circulating fibrinogen levels without causing complete depletion. This approach is designed to prevent post-injury venous thromboembolism (VTE) and thrombosis in trauma or mass-casualty settings by mitigating the dangerous post-injury fibrinogen surge while preserving baseline hemostasis and avoiding the bleeding risks associated with standard anticoagulants like low-molecular-weight heparin (LMWH).
- Other names
- siFga
02
Targets
FGA (Fibrinogen alpha chain)
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