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Siglec15
- Development stage
- Preclinical
- Lead developer
- NextCure
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Subcutaneous
01
Overview
Siglec15 is a membrane-bound lectin and an immunosuppressive transmembrane protein that functions as an inhibitory immune checkpoint. It plays a crucial role in regulating inflammatory processes, promoting cancer development by repressing T lymphocyte activation and proliferation, and facilitating tumor cell immune escape. Siglec15 is also implicated in osteoclast differentiation and bone remodeling. Its expression is often upregulated in various cancer types and is associated with an immunosuppressive tumor microenvironment, making it a significant target for novel immunotherapies.
- Other names
- SIGLEC15SIGLEC-15SIGLEC 15
02
Targets
SIGLEC15 (Sialic acid-binding immunoglobulin-like lectin 15)
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