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sigvotatug vedotin + pembrolizumab + cisplatin
- Development stage
- Phase 1
- Lead developer
- Pfizer
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
A combination regimen of **sigvotatug vedotin** (an investigational antibody-drug conjugate targeting nectin-4), **pembrolizumab** (a monoclonal antibody that inhibits PD-1, marketed as Keytruda), and **cisplatin** (a platinum-based chemotherapy). This combination is being investigated for the treatment of various advanced solid cancers, leveraging distinct and complementary mechanisms: sigvotatug vedotin delivers cytotoxic agents directly to tumor cells expressing nectin-4, pembrolizumab enhances immune-mediated tumor cell killing by releasing PD-1-mediated inhibition of T cells, and cisplatin induces tumor cell DNA damage leading to apoptosis, and also has immunomodulatory effects. No unique brand name for the combination.
- Brand names
- none for sigvotatug vedotin (investigational)none for cisplatin
02
Targets
DNAITGB6 (Integrin beta-4)PDCD1 (Programmed cell death protein 1 receptor)PVRL4 (Nectin cell adhesion molecule 4)
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