Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
siHOXA1
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
siHOXA1 is a small interfering RNA (siRNA) designed to silence the expression of the Homeobox A1 (HOXA1) gene. In oncology research, HOXA1 is recognized as a transcription factor involved in cell differentiation and proliferation, and its dysregulation is linked to various cancers, including breast cancer. Specifically, siHOXA1 is used to investigate the HOTAIRM1/HOXA1 axis, where HOXA1 overexpression contributes to acquired tamoxifen resistance in ER+ breast cancer cells. By knocking down HOXA1, siHOXA1 can restore tamoxifen sensitivity in resistant models like MCF7 (TAMR) cells. This reagent acts by promoting the degradation of HOXA1 mRNA, thereby reducing the protein levels of this homeodomain-containing transcription factor.
- Other names
- HOXA1 siRNAHOXA-1 siRNAHOXA 1 siRNAsiRNA targeting HOXA1
02
Targets
HOX (HOX transcription factor family)
Beyond the preview
Go deeper on siHOXA1.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on siHOXA1.