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Sihuang powder
- Development stage
- Unknown
- Lead developer
- The Second Affiliated Hospital of Nanchang University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Topical
01
Overview
Sihuang powder (四黄散) is a traditional Chinese medicine (TCM) topical formulation composed of four 'yellow' herbs, typically including *Phellodendron amurense* (Huang Bai), *Rheum palmatum* (Da Huang), *Scutellaria baicalensis* (Huang Qin), and *Coptis chinensis* (Huang Lian) or *Gardenia jasminoides* (Zhi Zi). It is widely utilized in clinical practice in China for the external treatment of inflammatory conditions, most notably infusion-induced phlebitis, as well as cellulitis and localized swelling. The formula is characterized by its 'heat-clearing,' 'detoxifying,' and 'blood-cooling' properties in TCM theory. Pharmacologically, its active constituents—such as berberine, baicalin, and emodin—exert anti-inflammatory effects by inhibiting pro-inflammatory cytokines and mediators. In the context of infusion-induced phlebitis, it is often applied as a wet compress or paste, sometimes combined with microwave irradiation to enhance therapeutic outcomes.
- Other names
- Sihuang sanSi Huang SanSi-Huang-SanSihuang powder external application
02
Targets
IL-6 (Interleukin 6)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TNFA (Tumor necrosis factor alpha (soluble))
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