Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
siInhba
- Development stage
- Preclinical
- Lead developer
- Seoul National University
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intralesional, Intratumoral, Parenteral
01
Overview
siInhba is a small interfering RNA (siRNA) designed to target and silence the expression of the Inhba gene, which encodes the inhibin beta A subunit (a component of activin A). Activin A is a member of the transforming growth factor-beta (TGF-beta) superfamily and a well-documented inducer of muscle atrophy. In preclinical models of periodontitis, local administration of siInhba into periodontitis-affected gingiva has been shown to significantly reduce serum activin A levels, thereby preventing systemic skeletal muscle atrophy and restoring muscle mass and myofiber size without causing apparent systemic adverse effects. Additionally, siInhba has been investigated in preclinical models of pancreatic ductal adenocarcinoma to prevent cancer-associated muscle wasting.
- Other names
- Inhba siRNAInhba small interfering RNAactivin A siRNAinhibin beta A siRNAsi-INHBA
02
Targets
Activin A
Beyond the preview
Go deeper on siInhba.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on siInhba.