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siKDM6A
- Development stage
- Preclinical
- Lead developer
- National Cancer Institute
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
siKDM6A is a small interfering RNA (siRNA) designed to silence the expression of the histone demethylase KDM6A (also known as UTX). In preclinical studies, particularly in glioblastoma stem-like cells (GSCs) and glioma cell lines, siKDM6A has been used to investigate the role of KDM6A in radiosensitivity. By knocking down KDM6A, the radiation-induced decrease of histone H3K27 tri-methylation (H3K27me3) is abolished, leading to a significant delay in the dispersal of γH2AX nuclear foci. This suggests that KDM6A inhibition or knockdown impairs DNA double-strand break (DSB) repair, thereby sensitizing glioblastoma cells to radiotherapy.
- Other names
- KDM6A siRNAKDM-6A siRNAKDM 6A siRNAsiRNA targeting KDM6A
02
Targets
KDM6A (Lysine-specific demethylase 6A)
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