sIL15-NK cells

sIL15-NK cells are Natural Killer (NK) cells genetically engineered to constitutively secrete Interleukin-15 (sIL15). This autocrine signaling approach is designed to enhance the persistence, expansion, and anti-tumor cytotoxicity of NK cells without the need for exogenous cytokine support. In preclinical models of Acute Myeloid Leukemia (AML), these cells demonstrate improved in vitro persistence and in vivo expansion compared to unmodified NK cells. The secretion of IL-15 induces a distinctly activated phenotype characterized by the upregulation of activating receptors such as NKp30, NKG2D, and LFA-1. While providing potent anti-tumor effects, constitutive systemic secretion of IL-15 has been associated with potential lethal toxicity in xenograft models, characterized by high levels of systemic hIL15 and hTNFα, necessitating careful evaluation for clinical translation.

Other names

IL-15 secreting NK cellsIL15 secreting NK cellsIL 15 secreting NK cellssecreted IL-15 NK cellsengineered IL-15 NK cells