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Group 2 silicone patch-University of Oklahoma-scar refers to the control intervention in a split-scar randomized clinical trial conducted by the University of Oklahoma Health Sciences Center. This intervention involves the application of a standard-of-care silicone patch to one-half of a vertical forehead scar following paramedian forehead flap reconstruction. Silicone patches are medical devices used to improve the healing and cosmetic appearance of scars by providing occlusion and hydration. This physical barrier helps to normalize the hydration of the stratum corneum, which in turn signals a reduction in fibroblast activity and collagen production, preventing the formation of hypertrophic or keloid scars. In this specific trial, the silicone patch serves as the comparator to evaluate the additive effects of topical cannabidiol (CBD) isolate.
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