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siLuc-LODER
- Development stage
- Preclinical
- Lead developer
- Silexion Therapeutics
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intratumoral
01
Overview
siLuc-LODER is an experimental RNA interference (RNAi) formulation consisting of a small interfering RNA (siRNA) targeting the luciferase gene, delivered via the LODER™ (Local Delivery EluteR) platform. Developed by Silenseed Ltd., the LODER™ is a miniature, biodegradable polymeric scaffold designed for intratumoral implantation. It provides sustained release of the siRNA payload over several months, aiming to achieve long-term gene silencing within the tumor microenvironment. In preclinical and clinical research, siLuc-LODER is primarily utilized as a non-therapeutic negative control to evaluate the sequence-specific efficacy of other siRNA-LODER products, such as siG12D-LODER, which targets mutated KRAS in pancreatic cancer. The delivery system is engineered to overcome physical barriers in solid tumors by utilizing a multi-step distribution process involving priming, convection, and diffusion.
- Other names
- siLuc-LODERTM
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