Drug intelligence / Profile preview

silver citrate

Development stage
Preclinical
Lead developer
Pure Bioscience
Modality
Small Molecules
Administration
Topical
01

Overview

Silver citrate is an experimental small molecule compound classified as a tricarboxylic acid derivative. It is the silver salt of citric acid and is also known as trisilver citrate or 2-hydroxy-1,2,3-propanetricarboxylic acid silver salt. Silver ions in this compound are stabilized by the citrate counter ion, which enhances their antimicrobial properties by increasing permeability into bacteria and preventing oxidation of the ionic form. The primary mechanism of action involves the release of antimicrobial silver ions (Ag+), which disrupt bacterial cell function through multiple pathways including binding to thiol groups in proteins (leading to protein denaturation) and interacting with DNA to inhibit replication. Silver compounds are under research for their potential use as antimicrobial agents due to rising resistance against conventional antibiotics[1][4][6].

Brand names
Silverion 2400Silverion2400Silverion-2400
Other names
2-hydroxy-1,2,3-propanetricarboxylic acid silver salttrisilver citrate
02

Targets

Streptococcus mutans cytoplasmic membraneNeuraminidase

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